The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in Heart Tissue of Diabetic Rats

Objective: It was reported exercise and herbal medicine can possess synergistic effects to control of diabetes complications. The purpose of the present study was investigation of the effects of high-intensity interval training (HIIT) and taking curcumin supplement on activity levels of GPX and MDA of heart tissue in diabetic rats. Materials and Methods: Thirty-two male Wistar rats were randomly divided to four groups of curcumin, training-placebo, training-curcumin, and control. The subjects had being trained to perform HIIT on treadmill and in the fashion of increasing manner. Diabetes was induced via injection of 50 (ml/Kg rat weight) STZ. Fifty (ml/kg rat weight) curcumin had being nourished to the animals of the curcumin groups, by using the gavage technique, during a period of eight weeks (five days a week). The rats were anesthetized via intraperitoneal injection of ketamine, 24 hours after the intervention. Then, heart tissues were separated from bodies of the rats to examine changes in GPX and MDA enzymes. Results: Activity levels of GPX enzyme of the three groups of curcumin, training-placebo, and training-curcumin increased significantly than correspondent levels of the control group. Activity levels of MDA enzyme of the three groups of curcumin, training-placebo, and training-curcumin decreased significantly than correspondent levels of the control group. Though, no significant difference was observed between those first three groups (P-value≤0.05). Discussion: The findings indicated that either HIIT or taking curcumin supplement or combination of both could solely contribute significant enhancement to activity levels of antioxidant enzymes and decreasing of Oxidative enzymes within heart tissues of diabetic mice. Although, those two interventions would not strengthen the influences of each other in decrease of MDA but they would strengthen the influences of each other in increasing of GPX.